What are the conditions favourable for dissociation of oxygen from...

Haemoglobin is a red coloured iron containing pigment present in the RBCs. O₂ can bind with haemoglobin in a reversible manner to form oxyhaemoglobin. A sigmoid curve is obtained when percentage saturation of haemoglobin with O₂ is plotted against the pO2. This curve is called the Oxygen dissociation curve and is highly useful in studying the effect of factors like pCO2, H⁺ concentration, etc., on binding of O₂ with haemoglobin. In the alveoli, where there is high pO2, low pCO2, lesser H⁺ concentration and lower temperature, the factors are all favourable for the formation of oxyhaemoglobin, whereas in the tissues, where low pO2, high pCO2, high H⁺ concentration and higher temperature exist, the conditions are favourable for dissociation of oxygen from the oxyhaemoglobin. This clearly indicates that O₂ gets bound to haemoglobin in the lung surface and gets dissociated at the tissues