Can typhoid fever be fatal?

In severe cases, typhoid fever can lead to intestinal perforation and death. Mary Mallon was a cook by profession and was a typhoid carrier who continued to spread typhoid for several years through the food she prepared. Salmonella typhi is a pathogenic bacterium which causes typhoid fever in human beings.Salmonella typhi is a pathogenic bacterium which causes typhoid fever in human beings. These pathogens generally enter the small intestine through food and water contaminated with them and migrate to other organs through blood. Sustained high fever (39° to 40°C), weakness, stomach pain, constipation, headache and loss of appetite are some of the common symptoms of this disease. Intestinal perforation and death may occur in severe cases.