Chemosensitive area of respiratory centre in medulla is affected by

Human beings have a significant ability to maintain and moderate the respiratory rhythm to suit the demands of the body tissues. A specialised centre present in the medulla region of the brain called respiratory rhythm centre is primarily responsible for this regulation. A chemosensitive area is situated adjacent to the rhythm centre which is highly sensitive to $\mathrm{CO}_2$ and hydrogen ions. Increase in these substances can activate this centre, which in turn can signal the rhythm centre to make necessary adjustments in the respiratory process.