Which one of the following correctly describes the sequence of events leading to muscle contraction following acetylcholine release at the neuromuscular junction?

Step-by-step solution

Release of acetylcholine at the neuromuscular junction generates an action potential in the sarcolemma. This action potential spreads through the muscle fibre and causes the release of calcium ions ( Ca ⁺⁺ ) from the sarcoplasmic reticulum into the sarcoplasm. The increase in Ca ⁺⁺ level leads to the binding of calcium with a subunit of troponin on actin filaments, thereby removing the masking of active sites for myosin. Utilising the energy from ATP hydrolysis, the myosin head binds to the exposed active sites on