- Exam
- JEE Main
- Year
- 2022
- Date
- 28 July
- Shift
- Evening Shift
- Subject
- Chemistry
- Chapter
- Chemistry in Everyday Life
JEE Main 2022 · 28 July · Evening Shift · Chemistry · Chemistry in Everyday Life
Two statements in respect of drug-enzyme interaction are given...
Two statements in respect of drug-enzyme interaction are given below
Statement I : Action of an enzyme can be blocked only when an inhibitor blocks the active site of the enzyme.
Statement II : An inhibitor can form a strong covalent bond with the enzyme.
In the light of the above statements. Choose the correct answer from the options given below
Options
- ABoth Statement I and Statement II are true
- BBoth Statement I and Statement II are false
- CStatement I is true but Statement II is false
- DStatement I is false but Statement II is true
Correct answer
D. Statement I is false but Statement II is true
Step-by-step solution
The first function of an enzyme is to hold the substrate for a chemical reaction. Active sites of enzymes hold the substrate molecule in a suitable position, so that it can be attacked by the reagent effectively.
Substrates bind to the active site of the enzyme through a variety of interactions such as ionic bonding, hydrogen bonding, van der Waals interaction or dipole-dipole interaction.
Drugs inhibit activities of enzymes. These can block the binding site of the enzyme and prevent the binding of substrate, or can inhibit the catalytic activity of the enzyme. Such drugs are called enzyme inhibitors
Some drugs do not bind to active sites. These bind to different site of enzyme called allosteric sites.
This binding of inhibitor at allosteric site changes the shape of the active site in such a way that substrate cannot recognise it