Fundamentals of Organic ChemistryChemistryAldehydes and Ketones
Identify the major product formed in the following reaction:
Correct answer
1
Step-by-step solution
The given starting material is heptane-2,6-dione, which is a 1,5-diketone. When a 1,5-diketone is treated with hydroxylamine ( NH₂OH ) in the presence of an acid catalyst ( H^+ ) and heat ( ), it undergoes a cyclization reaction to form a pyridine derivative. This is a standard method for the synthesis of pyridines. The reaction proceeds via the following steps: 1. The hydroxylamine reacts with one of the carbonyl groups to form a mono-oxime intermediate. 2. The nitrogen atom of the oxime then attacks the second ca