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Fundamentals of Organic ChemistryChemistryAldehydes and Ketones

Which of the following methods is most suitable for the reduction of a carbonyl compound to a hydrocarbon if the compound is sensitive to both strong acids and strong bases?

Options

  1. AThioacetal reduction
  2. BAll of these
  3. CWolff-Kishner reduction
  4. DClemmensen reduction

Correct answer

A. Thioacetal reduction

Step-by-step solution

Clemmensen reduction involves the use of zinc amalgam and concentrated hydrochloric acid, which provides a strongly acidic medium. It is not suitable for acid-sensitive compounds. Wolff-Kishner reduction involves the use of hydrazine and a strong base like potassium hydroxide or sodium hydroxide, which provides a strongly basic medium. It is not suitable for base-sensitive compounds. Thioacetal reduction (Mozingo reduction) involves the conversion of the carbonyl compound to a thioacetal using a dithiol in the pres

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