Fundamentals of Organic ChemistryChemistryAmines
Identify the major product of the following reaction, assuming water is continuously removed to drive the equilibrium: +
Correct answer
1
Step-by-step solution
The reaction involves a primary amine and a ketone (acetone) in the presence of an acid catalyst ( H^+ ). When a primary amine reacts with a ketone under acidic conditions, it undergoes a nucleophilic addition-elimination reaction (condensation) to form an imine (also known as a Schiff base). The reaction proceeds via the formation of a hemiaminal intermediate, which then loses a molecule of water to form the carbon-nitrogen double bond of the imine. The general reaction is: R-NH₂ + R'₂C=O H^+ R-N=CR'₂ + H₂O In thi