Fundamentals of Organic ChemistryChemistryBiomolecules
Which of the following reagents can be used to convert into ?
Options
- ANaBH ₄
- BH ₂ / Pd
- CCH ₃ MgBr
- DLiAlH ₄
Correct answer
D. LiAlH ₄
Step-by-step solution
The given transformation involves the reduction of a carboxylic acid group ( - COOH ) to a primary alcohol group ( - CH ₂ OH ) while the amino group ( - NH ₂ ) remains unaffected. NaBH ₄ is a mild reducing agent that reduces aldehydes and ketones but cannot reduce carboxylic acids. H ₂/ Pd is used for catalytic hydrogenation of multiple bonds and does not reduce carboxylic acids to alcohols under normal conditions. CH ₃ MgBr is a Grignard reagent which will undergo an acid-base reaction with the acidic proton of th