Fundamentals of Organic ChemistryChemistryBiomolecules
In DNA replication, which of the following is the complementary nucleotide sequence for the strand 5^ -ACGT- 3^ ?
Options
- A3^ -ACGT- 5^
- B5^ -TCGA- 3^
- C5^ -AGCT- 3^
- D3^ -TGCA- 5^
Correct answer
D. 3^ -TGCA- 5^
Step-by-step solution
The two strands of DNA are antiparallel and complementary to each other. The given DNA strand has the sequence 5^ -ACGT- 3^ . According to the complementary base pairing rules, Adenine (A) pairs with Thymine (T) and Cytosine (C) pairs with Guanine (G). Therefore, the complementary sequence reading from the 3^ end to the 5^ end will be 3^ -TGCA- 5^ . Answer: 3^ -TGCA- 5^