Fundamentals of Organic ChemistryChemistryBiomolecules
During the formation of osazone derivatives from aldohexoses and ketohexoses, which carbon atoms are involved in the reaction?
Options
- AC-1 and C-2
- BC-2 and C-3
- CC-2
- DC-1
Correct answer
A. C-1 and C-2
Step-by-step solution
Osazone formation is a reaction characteristic of reducing sugars, such as aldohexoses and ketohexoses, when treated with excess phenylhydrazine. In aldohexoses (like glucose), the reaction initiates at the C-1 aldehyde group to form a phenylhydrazone. Subsequently, the adjacent C-2 hydroxyl group is oxidized to a ketone, which then reacts with another molecule of phenylhydrazine to yield the osazone. In ketohexoses (like fructose), the reaction begins at the C-2 ketone group to form a phenylhydrazone. The adjacent