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Fundamentals of Organic ChemistryChemistryBiomolecules

During the formation of osazone derivatives from aldohexoses and ketohexoses, which carbon atoms are involved in the reaction?

Options

  1. AC-1 and C-2
  2. BC-2 and C-3
  3. CC-2
  4. DC-1

Correct answer

A. C-1 and C-2

Step-by-step solution

Osazone formation is a reaction characteristic of reducing sugars, such as aldohexoses and ketohexoses, when treated with excess phenylhydrazine. In aldohexoses (like glucose), the reaction initiates at the C-1 aldehyde group to form a phenylhydrazone. Subsequently, the adjacent C-2 hydroxyl group is oxidized to a ketone, which then reacts with another molecule of phenylhydrazine to yield the osazone. In ketohexoses (like fructose), the reaction begins at the C-2 ketone group to form a phenylhydrazone. The adjacent

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