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MHT CET202527 Apr 2025Evening ShiftChemistryAminesActual

Which of the following is Hofmann exhaustive alkylation?

Options

  1. AR CONH ₂ [ ] Br ₂, KOH _ ( aq ) R - NH ₂
  2. BR - NH ₂ [ excess ] R - X R ₄ + N X
  3. CR ₄ + N X [ ] moist Ag ₂ O Alkene + R ₃ ~N
  4. DR CN Na / C ₂ H ₅ OH R CH ₂ NH ₂

Correct answer

A. R CONH ₂ [ ] Br ₂, KOH _ ( aq ) R - NH ₂

Step-by-step solution

Hofmann exhaustive alkylation describes the reaction of an amine with excess alkyl halide to form a quaternary ammonium salt through successive alkylation steps. Option A shows Hofmann bromamide degradation, converting an amide to a primary amine with one less carbon. Option C depicts Hofmann elimination, decomposing a quaternary ammonium salt to form an alkene and tertiary amine. Option D represents nitrile reduction to a primary amine (Mendius reduction). Option B corresponds exactly to Hofmann exhaustive alkylat

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