Enzymes generally get destroyed at temperature of _______ ^ ^ C .

Enzymes are typically proteinaceous in nature. At high temperatures, the thermal energy disrupts the non-covalent interactions (like hydrogen bonds, ionic bonds, and hydrophobic interactions) that maintain the complex three-dimensional structure of the protein.

This loss of structural integrity is called denaturation. When denatured, the active site of the enzyme is destroyed, resulting in the loss of catalytic activity.

While different enzymes have different thermal stabilities, most enzymes from mesophilic organisms start to denature and get destroyed at temperatures above 40^{}^{\circ} \text{C}, and their activity is typically completely lost in the range of 60 - 70^{}^{\circ} \text{C}.

Therefore, the most appropriate temperature range among the given options at which enzymes generally get destroyed is 60 - 70^{}^{\circ} \text{C}.

Answer: $60-70$