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NEST2024BiologyBiomolecules (B)

Katalin Karikó and Drew Weissman were awarded the Nobel Prize in Physiology or Medicine for the year 2023 for their observation that pseudo-uridine ( ) incorporated mRNA (but not mRNA with normal bases A, U, G, and C) is better for RNA vaccine production. These observations paved the way for developing the RNA vaccine against SARS-CoV-2 (the vaccine produces the spike protein of the virus in a cell). The reason that

Options

  1. AThe innate immune system does not recognise the pseudo-uridine incorporated mRNA allowing translation of the s
  2. BUnmodified mRNA encoding spike protein cannot be translated by the ribosome.
  3. CAntigen-presenting cells can translate only pseudo-uridine incorporated mRNA.
  4. DSpike protein from unmodified mRNA cannot induce immune response.

Correct answer

A. The innate immune system does not recognise the pseudo-uridine incorporated mRNA allowing translation of the s

Step-by-step solution

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