Tissue damage alters the surface-adhesive behaviour of leukocytes resulting in leukocyte rolling. This involves several cycles of attachment and detachment of leukocytes on the surface of endothelial cells. Given that the typical rupture force for a ligand-receptor pair is 25 pN , multiple bonds must be formed at the same time to provide the necessary counterbalance to the shear force exerted by the flowing blood. Th