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NEST2023BiologyMicrobes in Human Welfare

A hospital witnessed an outbreak of a nosocomial (hospital-acquired) infection caused by Klebsiella pneumoniae. It showed resistance to antibiotics generally used for its treatment. Under the given scenario, the antibiotic resistance of this organism can be attributed to

Options

  1. Athe presence of antibiotic resistance gene acquired through horizontal transfer from other prevalent strains i
  2. Bsilent mutations in target sites of antibiotics.
  3. Cneutralisation of antibiotics by enzymes that target and inactivate these antibiotics.
  4. Dreduced permeability of these antibiotics due to the formation of a protective barrier.

Correct answer

D. reduced permeability of these antibiotics due to the formation of a protective barrier.

Step-by-step solution

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