NEETChemistryBiomolecules
Given below are two statements: one is labelled as Assertion (A) and the other is labelled as Reason (R). Assertion (A): Insulin is routinely administered to diabetic patients via subcutaneous injection rather than the oral route. Reason (R): The peptide bonds of insulin are susceptible to hydrolysis by proteolytic enzymes in the alimentary canal. In the light of the above statements, choose the most appropriate answ
Options
- ABoth (A) and (R) are correct and (R) is the correct explanation of (A)
- BBoth (A) and (R) are correct but (R) is not the correct explanation of (A)
- C(A) is correct but (R) is not correct
- D(A) is not correct but (R) is correct
Correct answer
A. Both (A) and (R) are correct and (R) is the correct explanation of (A)
Step-by-step solution
Assertion (A) is correct because insulin is a proteinaceous hormone and is administered via injection to diabetic patients to bypass the digestive system. Reason (R) is also correct and provides the accurate biochemical explanation for the assertion. Insulin consists of amino acids linked by peptide bonds. If administered orally, these peptide bonds would undergo hydrolysis by the action of proteolytic enzymes (proteases) in the alimentary canal, destroying the hormone's structure and biological activity. Thus, bot