Trace the correct chronological sequence of events for a newly synthesized secretory protein as it moves through the endomembrane system: (A) Modification into glycoprotein in Golgi cisternae (B) Synthesis by ribosomes on the rough endoplasmic reticulum (C) Release from the trans face in secretory vesicles (D) Packaging into transport vesicles at the endoplasmic reticulum (E) Fusion of vesicles with the cis face of t

Step-by-step solution

The endomembrane system functions in a coordinated manner to synthesize, modify, and transport proteins. First, the protein is synthesized by ribosomes attached to the rough endoplasmic reticulum (B). Next, the newly synthesized proteins are packaged into transport vesicles at the endoplasmic reticulum (D). These vesicles move towards the Golgi apparatus and fuse with its forming or cis face (E). Inside the Golgi cisternae, the proteins are modified (e.g., glycosylation to form glycoproteins) (A). Finally, the modi