NEETBotanyBiomolecules (B)
How does a competitive inhibitor work?
Options
- ABy increasing the binding of the substrate to the enzyme
- BBy decreasing the binding of the substrate to the enzyme
- CBy not affecting the binding of the substrate to the enzyme
- DNone
Correct answer
B. By decreasing the binding of the substrate to the enzyme
Step-by-step solution
When the inhibitor closely resembles the substrate in its molecular structure and inhibits the activity of the enzyme, it is known as competitive inhibitor. Due to its close structural similarity with the substrate, the inhibitor competes with the substrate for the substrate-binding site of the enzyme. Consequently, the substrate cannot bind and as a result, the enzyme action declines, e.g., inhibition of succinic dehydrogenase by malonate which closely resembles the substrate succinate in structure. Such competiti