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NEETZoologyMolecular Basis of Inheritance

DNA is a polymer of nucleotides which are linked to each other by 3’-5’ phosphodiester bond. To prevent polymerisation of nucleotides, which of the following modifications would you choose?

Options

  1. AReplace purine with pyrimidines
  2. BRemove/Replace 3′ OH group in deoxyribose
  3. CRemove/Replace 2′ OH group with some other group in deoxy ribose
  4. DBoth ‘b’ and ‘c’

Correct answer

B. Remove/Replace 3′ OH group in deoxyribose

Step-by-step solution

Removing 3′ OH group in deoxyribose will lead to the prevention of polymerization with 5’ end.

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