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NEETZoologyPrinciples of Inheritance and Variation

What does the given figure represent?

Options

  1. AThe amino acid composition of the relevant portion of α-chain of haemoglobin from an individual with sickle-ce
  2. BThe amino acid composition of the relevant portion of β-chain of haemoglobin from an individual with sickle-ce
  3. CThe amino acid composition of the relevant portion of α-chain of haemoglobin from a normal individual
  4. DThe amino acid composition of the relevant portion of β-chain of haemoglobin from a normal individual

Correct answer

B. The amino acid composition of the relevant portion of β-chain of haemoglobin from an individual with sickle-ce

Step-by-step solution

The defect is caused by the substitution of Glutamic acid (Glu) by Valine (Val) at the sixth position of the beta globin chain of the haemoglobin molecule. The substitution of amino acid in the globin protein results due to the single base substitution at the sixth codon of the beta globin gene from GAG to GUG.

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