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NEETZoologyPrinciples of Inheritance and Variation

Select the incorrect statement for the given figure.

Options

  1. AThe disease is controlled by a single pair of alleles, HbA and HbS.
  2. BThe defect is caused by the substitution of Glutamic acid(Glu) by Valine (Val) at the sixth position of the be
  3. CThe mutant haemoglobin molecule undergoes polymerisation under high oxygen tension causing the change in the s
  4. DThe substitution of amino acid in the globin protein results due to the single base substitution at the sixth

Correct answer

C. The mutant haemoglobin molecule undergoes polymerisation under high oxygen tension causing the change in the s

Step-by-step solution

The disease is controlled by a single pair of alleles, HbA and HbS. The defect is caused by the substitution of Glutamic acid(Glu) by Valine (Val) at the sixth position of the beta globin chain of the haemoglobin molecule. The substitution of amino acid in the globin protein results due to the single base substitution at the sixth codon of the beta globin gene from GAG to GUG. The mutant haemoglobin molecule undergoes polymerisation under low oxygen tension causing the change in the shape of the RBC from biconcave

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