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NEETZoologyPrinciples of Inheritance and Variation

Read the following statements regarding sickle cell anaemia: (A) It is an autosome linked dominant trait that can be transmitted from parents to the offspring. (B) The defect is caused by the substitution of Glutamic acid by Valine in the haemoglobin molecule. (C) The substitution of the amino acid occurs at the sixth position of the alpha globin chain. (D) The mutant haemoglobin molecule undergoes polymerisation und

Options

  1. ATwo
  2. BOne
  3. CThree
  4. DFour

Correct answer

A. Two

Step-by-step solution

Statement (A) is incorrect because sickle cell anaemia is an autosome linked recessive trait, not a dominant trait. Statement (B) is correct as the disease is caused by the substitution of Glutamic acid by Valine. Statement (C) is incorrect because the substitution of the amino acid occurs at the sixth position of the beta globin chain, not the alpha globin chain. Statement (D) is correct because the mutant haemoglobin molecule undergoes polymerisation under low oxygen tension, causing the change in the shape of th

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