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NEETZoologyPrinciples of Inheritance and Variation

Match List-I with List-II. List-I List-II (A) Sickle-cell anaemia (I) Quantitative defect in globin chain synthesis (B) Thalassemia (II) Sex-linked recessive defect in blood clotting cascade (C) Phenylketonuria (III) Substitution of Glutamic acid by Valine (D) Haemophilia (IV) Lack of an enzyme that converts phenylalanine to tyrosine Choose the correct answer from the options given below:

Options

  1. A(A) - (I), (B) - (III), (C) - (II), (D) - (IV)
  2. B(A) - (III), (B) - (I), (C) - (IV), (D) - (II)
  3. C(A) - (III), (B) - (I), (C) - (II), (D) - (IV)
  4. D(A) - (I), (B) - (III), (C) - (IV), (D) - (II)

Correct answer

B. (A) - (III), (B) - (I), (C) - (IV), (D) - (II)

Step-by-step solution

Sickle-cell anaemia is an autosomal recessive disorder caused by the substitution of Glutamic acid by Valine at the sixth position of the beta-globin chain. Thalassemia is a quantitative defect resulting in a reduced rate of synthesis of globin chains. Phenylketonuria is an inborn error of metabolism caused by the lack of the enzyme phenylalanine hydroxylase, which converts phenylalanine to tyrosine. Haemophilia is a sex-linked recessive disorder where a single protein involved in the blood clotting cascade is affe

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