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NEETZoologyPrinciples of Inheritance and Variation

Given below are two statements: one is labelled as Assertion (A) and the other is labelled as Reason (R). Assertion (A): Sickle-cell anaemia is a qualitative problem of synthesising an incorrectly functioning globin, whereas Thalassemia is a quantitative problem. Reason (R): Sickle-cell anaemia is caused by a mutation resulting in a reduced rate of synthesis of globin chains, while Thalassemia is caused by a point mu

Options

  1. ABoth (A) and (R) are correct and (R) is the correct explanation of (A)
  2. BBoth (A) and (R) are correct but (R) is not the correct explanation of (A)
  3. C(A) is correct but (R) is incorrect
  4. D(A) is incorrect but (R) is correct

Correct answer

C. (A) is correct but (R) is incorrect

Step-by-step solution

Assertion (A) is correct because Sickle-cell anaemia involves the synthesis of an abnormal, incorrectly functioning globin chain (qualitative defect), whereas Thalassemia involves a reduced rate of synthesis of normal globin chains (quantitative defect). Reason (R) is incorrect because the molecular mechanisms are swapped in the statement. Sickle-cell anaemia is caused by a point mutation that substitutes Glutamic acid with Valine at the sixth position of the beta-globin chain. Thalassemia is caused by mutations or

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