NEET2012ZoologyPrinciples of Inheritance and VariationActual
Assertion : Hb ^ s Hb ^ s denotes the homozygous condition for sickle-cell anaemia. Reason : It occurs due to substitution of glutamic acid by valine at the 6^ th position of -chain of Hb .
Options
- AIf both assertion and reason are true and reason is the correct explanation of assertion
- BIf both assertion and reason are true but reason is not the correct explanation of assertion
- CIf assertion is true but reason is false
- DIf both assertion and reason are false
Correct answer
B. If both assertion and reason are true but reason is not the correct explanation of assertion
Step-by-step solution
Sickle cell anaemia is an autosomal hereditary disorder in which the erythrocytes become sickle shaped. The disorder or disease is caused by the formation of an abnormal haemoglobin called haemoglobin-s denoted as Hbs. Thus, the genotype of an individual homozygous for sickle cell anaemia is written as HbsHbs.