Mature RBCs lose their ability for

Matured mammalian RBCs do not have cell organelles including nucleus, Golgi bodies, mitochondria, ribosomes, centrioles and endoplasmic reticulum. It increases the surface area of RBCs and enables them to contain more haemoglobin. In the absence of cell organelles, the consumption of oxygen is very low and thus anaerobic respiration occurs in RBCs. Mature RBCs cannot replicate and cannot synthesise RNA as they do not possess machinery required (e.g., various enzymes) for replication and RNA synthesis.