AIIMS2012BotanyCell Cycle and Cell Division

Microtubule depolymerizing drug such as colchicine is expected to

Options

Ainhibit spindle formation during mitosis
Binhibit cytokinesis
Callow mitosis beyond metaphase
Dinduce formation of multiple contractile rings.

Correct answer

A. inhibit spindle formation during mitosis

Step-by-step solution

Colchicine is an alkaloid derived from the autumn crocus, Colchicum autumnale. It inhibits spindle formation in cells during mitosis so that chromosomes cannot separate during anaphase, thus inducing multiple sets of chromosomes. It does not affect cytokinesis.

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