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JIPMER2016ZoologyMolecular Basis of Inheritance

Consider these sentances regarding to the structure and nature of DNA. I. DNA has two pyrimidine bases which contain single ring structure. II. In DNA, composition of bases should be A+T G+C =1 . III. Each base pair of DNA is 3.4 Å apart from othes base pair. IV. The nucleosome model DNA packaging was proposed by Kornberg and Thomas. Choose the correct statements from given options.

Options

  1. AI and III
  2. BI, II and III
  3. CII, III and IV
  4. DI, III and IV

Correct answer

D. I, III and IV

Step-by-step solution

Erwin Chargaff (1950) made quantitative analysis of DNA and showed that the composition of DNA molecules varies in complex ways depending upon the source of DNA. He proposed Base Equivalence rule or Chargaff's rule, which states that, for double-stranded DNA, the proportion of adenine always equals to that of thymine and proportion of guanine always equals to that of cytosine, i.e. A = T and G = C . It follows that, an equal proportion of purines and pyrimidines is always seen in a double-stranded DNA, i.e. A+G=T+C

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