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JIPMER2007ZoologyPrinciples of Inheritance and Variation

Haemophilia is more commonly seen in human males than in human females because

Options

  1. Athis disease is due to an X-linked dominant mutation
  2. Ba greater proportion of girls die in infancy
  3. Cthis disease is due to an X-linked recessive mutation
  4. Dthis disease is due to a Y-linked recessive mutation

Correct answer

C. this disease is due to an X-linked recessive mutation

Step-by-step solution

Haemophilia, a hereditary (recessive X-linked) disease is caused due to fault in genes, which controlling the factor VIII and IX, located on X-chromosome. The male carries only one X-chromosome, his other sex chromosome, which carries no genes for blood clotting, so the condition is usually seen only in males where only one faulty chromosome is needed. While a female with one faulty X-chromosome will be carrier. So, in females two faulty X-chromosomes are needed to cause the disease.

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