NEET2017BotanyCell Cycle and Cell DivisionActual
Anaphase promoting complex (APC) is a protein degradation machinery necessary for proper mitosis of animal cells. If APC is defective in a human cell, which of the following is expected to occur?
Options
- AChromosomes will not condense
- BChromosomes will be fragmented
- CChromosomes will not segregate
- DRecombination of chromosome arms will occur
Correct answer
C. Chromosomes will not segregate
Step-by-step solution
Anaphase Promoting Complex (APC) is a protein necessary for the separation of daughter chromosomes during anaphase. APC degenerates proteins binding the two chromatids in the region of the centromere. As a result, the centromere of each chromosome divides. If APC is defective, then the chromosomes will fail to segregate during anaphase.