Which of the following hormones can play a significant role in...

Estrogen and parathyroid hormone play a significant role in osteoporosis. It is caused due to the deficiency of estrogen and excessive activity of parathormone. Estrogen helps to promote the activity of osteoblast they help in the formation of bone cells and inhibits osteoclast that destructs the bones. On the other hand, parathormone promotes the mobilization of calcium from bones into blood, hence causes demineralization.

The other listed hormones also contribute to osteoporosis but their effects are insignificant or very less, e.g., low level of progesterone and aldosterone causes bone loss, whereas the raised level of prolactin has been linked with osteoporosis.