NEET2007ZoologyMolecular Basis of InheritanceActual
During transcription, RNA polymerase holoenzyme binds to a gene promoter and assumes a saddle - like structure. What is it's DNA-binding sequence?
Options
- AAATT
- BCACC
- CTATA
- DTTAA.
Correct answer
C. TATA
Step-by-step solution
The DNA binding sequence for RNA polymerase is called TATA box. The TATA box is present in the eukaryotic promoter region. It is a 7-bp long regionlocated 20 bp upstream to the start point. It is surrounded by GC rich sequences. During the process of transcription, the RNA polymerase (a holoenzyme which has a core unit and a sigma factor for properinitiation oftranscription) binds to the TATA box because of which DNA assumes a saddle-like structure at this place. Related Theory In molecular biology, the TATA box (a