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NEET2007ZoologyMolecular Basis of InheritanceActual

During transcription, RNA polymerase holoenzyme binds to a gene promoter and assumes a saddle - like structure. What is it's DNA-binding sequence?

Options

  1. AAATT
  2. BCACC
  3. CTATA
  4. DTTAA.

Correct answer

C. TATA

Step-by-step solution

The DNA binding sequence for RNA polymerase is called TATA box. The TATA box is present in the eukaryotic promoter region. It is a 7-bp long regionlocated 20 bp upstream to the start point. It is surrounded by GC rich sequences. During the process of transcription, the RNA polymerase (a holoenzyme which has a core unit and a sigma factor for properinitiation oftranscription) binds to the TATA box because of which DNA assumes a saddle-like structure at this place. Related Theory In molecular biology, the TATA box (a

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