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NEET2023ZoologyPrinciples of Inheritance and VariationActual

In which disorder change of single base pair in the gene for beta globin chain results in change of glutamic acid to valine?

Options

  1. AHaemophilia
  2. BPhenylketonuria
  3. CThalassemia
  4. DSickle cell anaemia

Correct answer

D. Sickle cell anaemia

Step-by-step solution

Sickle-cell anaemia is caused by mutation of the gene controlling -chain of haemoglobin. Due to this mutation, glutamic acid present at 6^ th position of the -chain is replaced by amino acid valine.

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