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NEET 2023
Exam
NEET
Year
2023
Subject
Zoology
Chapter
Principles of Inheritance and Variation

NEET 2023 · Zoology · Principles of Inheritance and Variation

Select the correct statements about sickle cell anaemia. (A) There...

Select the correct statements about sickle cell anaemia. (A) There is a change in gene for beta globin. (B) In the beta globin, there is valine in the place of Lysine. (C) It is an example of point mutation. (D) In the normal gene UU is replaced by AA. Choose the correct answer from the options given below:

Options

  1. A(A),(B)(A), (B) and (D)(D) only
  2. B(A)(A) and (C)(C) only
  3. C(B)(B), (C)(C) and (D)(D) only
  4. D(B)(B) and (D)(D) only

Correct answer

B. (A)(A) and (C)(C) only

Step-by-step solution

Sickle cell anaemia is caused by the substitution of Glutamic acid by valine at the sixth position of the beta globin chain of the haemoglobin molecule. It is an example of point mutation. The substitution of amino acid in the globin protein results due to the single base substitution at the sixth codon of the beta globin gene from GAG to GUG. Thus, option (2) is correct
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