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NEET2009ZoologyPrinciples of Inheritance and VariationActual

Sickle cell anaemia is

Options

  1. Aan autosomal linked dominant trait
  2. Bcaused by substitution of valine by glutamic acid in the -globin chain of haemoglobin
  3. Ccaused by a change in base pair of DNA
  4. Dcharacterized by elongated sickle like RBC with a nucleus

Correct answer

C. caused by a change in base pair of DNA

Step-by-step solution

Sickle-cell anaemia is caused by a change in a single base pair of DNA. It is a genetic disease reported from negroes. The individuals of sickle-cell anaemia are immune to malaria.

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