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NEET2006ZoologyPrinciples of Inheritance and VariationActual

Cri-du-chat syndrome in humans is caused by the:

Options

  1. Atrisomy of 21^ st chromosome
  2. Bfertilization of an XX egg by a normal Y-bearing sperm
  3. Closs of half of the short arm of chromosome 5
  4. Dloss of half of the long arm of chromosome 5

Correct answer

C. loss of half of the short arm of chromosome 5

Step-by-step solution

Cri-du-chat (cat's cry) syndrome, also known as 5p- (5p minus) syndrome is caused by a partial deletion (monosomy) of a varying length of the short arm (p) of chromosome 5. Infants with this condition often have a high-pitched cry that sounds like that of a cat. Down syndrome occurs due to trisomy of 21^ st chromosome. Klinefelter syndrome is a genetic condition that results when a boy is born with an extra copy of the X chromosome.

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