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NEET2005ZoologyPrinciples of Inheritance and VariationActual

Haemophilia is more commonly seen in human males than in human females because:

Options

  1. Aa greater proportion of girls die in infancy
  2. Bthis disease is due to a Y-linked recessive mutation
  3. Cthis disease is due to an X-linked recessive mutation
  4. Dthis disease is due to an X-linked dominant mutation.

Correct answer

C. this disease is due to an X-linked recessive mutation

Step-by-step solution

Haemophilia being a sex chromosome related recessive disorder has its gene present on X chromosome. Since males have one X and one Y chromosome, and the genes present on X don't have counter genes on Y , only one affected gene (to be present on X ) is required for the disease in males. While in females, there are 2 X chromosomes. For the disease to occur both the X chromosomes should have the affected genes which is a rare chance. For this to be possible, the father of the female must be diseased while the mother m

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