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NEST2020BiologyBiomolecules (B)

Three given polypeptides ( P , Q and R ) , of same size and same pI (7.2) , have a single aspartic acid in each of them. In polypeptide P , the aspartic acid residue is on the surface. In polypeptide Q , it is surrounded by negatively charged residues, whereas in polypeptide R it is deeply buried in a hydrophobic core. pKa of the side chain carboxylate of free (in solution) aspartic acid is 3.65 . The polypeptides ar

Options

  1. Aremain the same in P , modest increase in Q and greater increase in R.
  2. Bremain the same in all the three polypeptides
  3. Cincrease in P , decrease in Q and remain the same in R
  4. Dremain the same in P , increase Q and decrease in R

Correct answer

A. remain the same in P , modest increase in Q and greater increase in R.

Step-by-step solution

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