Scientists find a gene P that helps human peripheral neurons to sense temperature less than 13^ C and induce a physiological signal of avoidance. This gene is present in almost all vertebrates. Considering that gene P has role only in detection of low temperature, the correct statement(s) is(are) ___.

Options

1. AGene P is beneficial for humans as it warns the body against low temperature.
2. BLoss-of-function mutant of gene P most likely survive in ambient temperature in laboratory conditions.
3. CGene P may be lost in fish that live in cold waters.
4. DGene P must be hyperactivated in fish that live in cold water.