The CENTN1 gene encodes the protein centrin that is localized to the centriolar apparatus. Mutation in this gene may give rise to dysfunctional cilia leading to respiratory disorders with different degrees of severity. Fifty thousand individuals of a Caucasian population with a range of respiratory illnesses were analyzed for mutations in this gene. The red mark on the respective regions of the genes are the position

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1. AIn case 4 , a truncated protein is made from a normally spliced mRNA resulting in functional cilia, thereby no
2. BIn case 3, a mutation resulted in a stop codon, resulting in partially functional cilia and hence individuals
3. CIn case 2 , an intact mutated or truncated protein is produced resulting in dysfunctional cilia and individual
4. DIn case 1 , the gene is not transcribed, and no protein is produced resulting in dysfunctional cilia and indiv