NTA Abhyas NEET2020ChemistryBiomoleculesPractice
Select the option which is not correct with respect to enzyme action.
Options
- ASubstrate binds with enzyme at its active site to form enzyme substrate complex.
- BAddition of lot of succinate does not reverse the inhibition of succinic dehydrogenase by malonate.
- CA noncompetitive inhibitor cannot bind the active site of the enzyme at a site distinct from that which binds
- DMalonate is a competitive inhibitor of succinic dehydrogenase.
Correct answer
B. Addition of lot of succinate does not reverse the inhibition of succinic dehydrogenase by malonate.
Step-by-step solution
The reduction of activity of succinate dehydrogenase by malonate is an example of competitive inhibition. Competitive inhibition is a reversible inhibition where inhibitor competes with the normal substrate for the active site of the enzyme. A competitive inhibitor is usually similar to the normal substrate and, therefore, fits the active site of an enzyme and binds with it. Since a competitive inhibitor occupies the site only temporarily, the enzyme action is not permanently affected. Thus, addition of a lot of su