NEETZoologyBiotechnology and Its Applications
Human insulin is being commercially produced from a transgenic species of
Options
- ARhizobium
- BSaccharomyces
- CEscherichia
- DMycobacterium
Correct answer
C. Escherichia
Step-by-step solution
In mammals, including humans, insulin is synthesised as a prohormone (like a pro-enzyme, the pro-hormone also needs to be processed before it becomes a fully mature and functional hormone) which contains an extra stretch called the C peptide. This C peptide is not present in the mature insulin and is removed during maturation into insulin.The main challenge for production of insulin using rDNA techniques was getting insulin assembled into a mature form. In 1983, Eli Lilly, an American company prepared two DNA seque