Maturation of insulin involves removal of

Step-by-step solution

In mammals, including humans, insulin is synthesised as a prohormone (like a pro-enzyme, the pro-hormone also needs to be processed before it becomes a fully mature and functional hormone) which contains an extra stretch called the C peptide. This C peptide is not present in the mature insulin and is removed during maturation into insulin.The main challenge for production of insulin using rDNA techniques was getting insulin assembled into a mature form. In 1983, Eli Lilly, an American company prepared two DNA seque