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NEETZoologyBiotechnology and Its Applications

C-peptide of human insulin is

Options

  1. AA part of mature insulin molecule
  2. BResponsible for formation of disulphide bridges
  3. CRemoved during maturation of proinsulin to insulin
  4. DResponsible for its biological activity

Correct answer

C. Removed during maturation of proinsulin to insulin

Step-by-step solution

In mammals, including humans, insulin is synthesised as a prohormone (like a pro-enzyme, the pro-hormone also needs to be processed before it becomes a fully mature and functional hormone) which contains an extra stretch called the C peptide. This C peptide is not present in the mature insulin and is removed during maturation into insulin.The main challenge for production of insulin using rDNA techniques was getting insulin assembled into a mature form. In 1983, Eli Lilly, an American company prepared two DNA seque

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