Match List I with List II regarding the treatment of Adenosine Deaminase (ADA) deficiency. List I List II A. Retroviral vector I. Stage at which gene introduction can offer a permanent cure B. Lymphocytes II. Treatment involving injection of functional ADA that is not completely curative C. Early embryonic stages III. Used to introduce functional ADA cDNA into target cells D. Enzyme replacement therapy IV. Target cel

Step-by-step solution

In the gene therapy of ADA deficiency, a retroviral vector is used to introduce functional ADA cDNA into the target cells (A matches III). Lymphocytes are the target cells extracted from the patient's blood and grown in culture for genetic engineering (B matches IV). Introducing the gene isolated from marrow cells producing ADA into cells at early embryonic stages could be a permanent cure (C matches I). Enzyme replacement therapy involves the injection of functional ADA into the patient, but it is not completely c