Read the following statements regarding the mechanism of action of Bt toxin and arrange them in the correct chronological order: A. Creation of pores in the midgut epithelial cells B. Ingestion of inactive protoxin by the insect C. Swelling and lysis of cells leading to death D. Binding of active toxin to the surface of midgut epithelial cells E. Solubilisation of protein crystals by alkaline pH Choose the correct se

Step-by-step solution

The correct chronological sequence of events for the action of Bt toxin is as follows. First, the insect ingests the inactive toxin or protoxin (Statement B). Next, in the insect gut, the alkaline pH solubilises the protein crystals, converting the inactive protoxin into an active form (Statement E). The activated toxin then binds to the surface of the midgut epithelial cells (Statement D). This binding creates pores in the epithelial cells (Statement A). Finally, the pores cause cell swelling and lysis, eventually