NEETZoologyBiotechnology and Its Applications
Given below are two statements: one is labelled as Assertion (A) and the other is labelled as Reason (R). Assertion (A): Insulin produced by the American company Eli Lilly using rDNA technology did not require the removal of C-peptide to become active. Reason (R): Eli Lilly prepared two separate DNA sequences corresponding to A and B chains of human insulin and introduced them into plasmids of Escherichia coli to pro
Options
- ABoth Assertion (A) and Reason (R) are true but Reason (R) is not the correct explanation of Assertion (A).
- BBoth Assertion (A) and Reason (R) are true and Reason (R) is the correct explanation of Assertion (A).
- CAssertion (A) is true but Reason (R) is false.
- DAssertion (A) is false but Reason (R) is true.
Correct answer
B. Both Assertion (A) and Reason (R) are true and Reason (R) is the correct explanation of Assertion (A).
Step-by-step solution
Assertion (A) is true because the recombinant insulin produced by Eli Lilly was already in its mature form (consisting of only A and B chains) and did not have the C-peptide that needs to be removed. Reason (R) is true and correctly explains the Assertion. In 1983, Eli Lilly bypassed the pro-hormone stage by preparing two separate DNA sequences corresponding to the A and B chains of human insulin. These sequences were introduced into plasmids of Escherichia coli to produce the chains separately. The chains were the