NEETZoologyBiotechnology and Its Applications
Match List-I with List-II regarding the structure and maturation of insulin. List-I List-II (A) Pro-insulin (I) Removed during maturation (B) Mature insulin (II) Links chain A and chain B (C) C-peptide (III) Contains chains A, B and C (D) Disulphide bridge (IV) Consists of only two polypeptide chains Choose the correct answer from the options given below:
Options
- A(A)-(III), (B)-(IV), (C)-(I), (D)-(II)
- B(A)-(IV), (B)-(III), (C)-(I), (D)-(II)
- C(A)-(III), (B)-(IV), (C)-(II), (D)-(I)
- D(A)-(IV), (B)-(III), (C)-(II), (D)-(I)
Correct answer
A. (A)-(III), (B)-(IV), (C)-(I), (D)-(II)
Step-by-step solution
(A) Pro-insulin is the inactive precursor form of insulin, which contains three polypeptide chains: A, B, and an extra stretch called the C-peptide. Thus, (A) matches with (III). (B) Mature insulin is the active hormone that consists of only two short polypeptide chains: chain A and chain B. Thus, (B) matches with (IV). (C) C-peptide is the extra stretch of polypeptide present in pro-insulin that is removed during its maturation into active insulin. Thus, (C) matches with (I). (D) Disulphide bridges are the covalen