Given,
The tangents at the points P and Q on the circle x2+y2−2x+y=5 meet at the point R(49,2),
Now plotting the diagram of the above data we have,

Now we know that,
Length of tangent is given by, PR=QR=S1
So, L=S1=(49)2+(2)2−2×49+2−5
⇒L=45
Now distance between CR will be, CR=(49−1)2+(2+21)2=1625+425=16125=455
Now finding PQ by equating area, we get
21×25×L=21×2PQ×CR
⇒21×25×45=21×2PQ×455
⇒PQ=5
Now finding area of triangle PQR by heron's formula,
s=425+5
So, area will be ∆=s(s−a)(s−b)(s−c)
⇒∆=425+5(425+5−45)(425+5−45)(425+5−5)
⇒∆=425+5(425)(425)(45−25)
⇒∆=(45)(1625−20)=85